McGuane had a wretched run with injuries since coming to Brisbane at the start of 2014, but had played his best football in the past month, kicking seven goals in four games.
"My body has given up on me and as much as Iíd love to continue to play on, it's clear my body won't deal with it," McGuane said.
"Iím obviously really disappointed Ė getting back out there and playing the last four games has been incredibly enjoyable, and something I wasnít sure was going to happen after all the injuries I've had over the last few years.
"Iíll have very fond memories of my career and am happy to have got to play so long in the AFL systemÖ I feel blessed to have had such a long career in the AFL.
"Itís been hard too, because Iíve been injured for 90 per cent of my time here, but it was great to finish off my career up here with my family around me."